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It can be used for token generation in Orzhov-style decks, and a control deck relying on this might work in Azorius splashing red

Amzu, Swarms Hunger Amzu, Swarm's Hunger is a good insect lord as a menace enabler, and it synergizes well with what many Golgari insect decks want to do with its trigger when cards leave your graveyard

Tellah, Great Sage specifies that if you cast a spell with eight or more mana, you have to sacrifice Tellah, but you at least get to deal damage equal to the mana cost to each opponent

For example, if an effect has given a 2/2 creature -4/-0 so that it's a -2/2 creature, doubling its power and toughness gives it -2/+2, and it becomes a -4/4 creature